Charcoal Hemoperfusion and Methotrexate Toxicity

Charcoal hemoperfusion for phenytoin intoxication.

Accidental ingestion of phenytoin can lead to severe neurological sequelae. Charcoal hemoperfusion decreases phenytoin levels but has never been reported before in children. We present a child with accidental ingestion of phenytoin who responded to charcoal hemoperfusion.

High-dose continuous venovenous hemofiltration combined with charcoal hemoperfusion for methotrexate removal

Methotrexate (MTX) is used to treat various disorders and can be safely administered at high doses if renal function is adequate, high urine output (UOP) is maintained, urine is alkalinized and leucovorin rescue is given. Despite those measures, toxicity (mucositis, diarrhea, renal dysfunction and myelosuppression) occurs with prolonged high serum drug concentrations [1]. Dialysis-based methods...

Charcoal hemoperfusion in the treatment of levothyroxine intoxication.

BACKGROUND Levothyroxine (l-thyroxine) intoxication may arise from intentional or accidental ingestion of excessive doses of the hormone and may cause symptoms equivalent to thyroid storm. We report a case of massive accidental l-thyroxine intoxication resulting from an error in the preparation of capsules to treat goiter. SUMMARY A 61-year-old woman was admitted showing high levels of thyroi...

Use of activated charcoal for hemoperfusion in Dutch rabbits.

Higher efficacy of direct hemoperfusion using coated activated-charcoal column for disopyramide poisoning

RATIONALE Cases of severe disopyramide poisoning are rare and few have been reported. We report a case in which activated-charcoal column hemoperfusion was dramatically effective for life-threatening disopyramide poisoning. PATIENT CONCERNS A teenage girl who had overdosed on disopyramide (total dose, 4950 mg) was brought to our hospital. She was resuscitated from short period cardiopulmonary...